Authors:
Robert T. Knight
Hans-Jochen Heinze
Celine Bueche
Cheryl Hawkes
Cornelia Garz
Stefan Vielhaber
Johannes Attems
Klaus Reymann
Roxana Carare
Stefanie Schreiber
Date: 2014
DOI: 10.1002/acn3.27
Abstract:
There is substantial controversy regarding the causative role of amyloid b (Ab)deposition in Alzheimer’s disease (AD). The cerebrovasculature plays an impor-tant role in the elimination of Ab from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats(SHRSP), an animal model of chronic arterial hypertension, cerebral small ves-sel disease (CSVD) leads to age-dependent parenchymal Ab accumulation simi-lar to that observed in AD. These data approve the neuropathological linkbetween CSVD and AD, confirm the challenge that parenchymal Ab depositionis a specific marker for AD and disclose the meaning of SHRSP as valid experi-mental model to investigate the association between hypertension, CSVD, and Ab plaques.