Roxana Carare

Hypertension drives parenchymal b -amyloid accumulationin the brain parenchyma

Authors:

  • Robert T. Knight

  • Hans-Jochen Heinze

  • Celine Bueche

  • Cheryl Hawkes

  • Cornelia Garz

  • Stefan Vielhaber

  • Johannes Attems

  • Klaus Reymann

  • Roxana Carare

  • Stefanie Schreiber

Date: 2014

DOI: 10.1002/acn3.27

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Abstract:

There is substantial controversy regarding the causative role of amyloid b (Ab)deposition in Alzheimer’s disease (AD). The cerebrovasculature plays an impor-tant role in the elimination of Ab from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats(SHRSP), an animal model of chronic arterial hypertension, cerebral small ves-sel disease (CSVD) leads to age-dependent parenchymal Ab accumulation simi-lar to that observed in AD. These data approve the neuropathological linkbetween CSVD and AD, confirm the challenge that parenchymal Ab depositionis a specific marker for AD and disclose the meaning of SHRSP as valid experi-mental model to investigate the association between hypertension, CSVD, and Ab plaques.