Electrophysiological Decoding of Spatial and Color Processing in Human Prefrontal Cortex

Abstract:

The prefrontal cortex (PFC) plays a pivotal role in goal-directed cognition, yet its representational code remains an open problem with decoding techniques ineffective in disentangling task-relevant variables from PFC. Here we applied regularized linear discriminant analysis to human scalp EEG data and were able to distinguish a mental-rotation task versus a color-perception task with 87% decoding accuracy. Dorsal and ventral areas in lateral PFC provided the dominant features dissociating the two tasks. Our findings show that EEG can reliably decode two independent task states from PFC and emphasize the PFC dorsal/ventral functional specificity in processing the where rotation task versus the what color task.

Authors:

• Byoung-Kyong Min

• Hyun-Seok Kim

• Wonjun Ko

• Min-Hee Ahn

• Heung-Il Suk

• Dimitrios Pantazis

• Robert T Knight

Date: 2021

DOI: https://doi.org/10.1016/j.neuroimage.2021.118165

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Lateral prefrontal cortex lesion impairs regulation of internally and externally directed attention

ABSTRACT

According to the competition account of lexical selection in word production, conceptually driven word retrieval involves the activation of a set of candidate words in left temporal cortex and competitive selection of the intended word from this set, regulated by frontal cortical mechanisms. However, the relative contribution of these brain regions to competitive lexical selection is uncertain. In the present study, five patients with left prefrontal cortex lesions (overlapping in ventral and dorsal lateral cortex), eight patients with left lateral temporal cortex lesions (overlapping in middle temporal gyrus), and 13 matched controls performed a picture-word interference task. Distractor words were semantically related or unrelated to the picture, or the name of the picture (congruent condition). Semantic interference (related vs. unrelated), tapping into competitive lexical selection, was examined. An overall semantic interference effect was observed for the control and left-temporal groups separately. The left-frontal patients did not show a reliable semantic interference effect as a group. The left-temporal patients had increased semantic interference in the error rates relative to controls. Error distribution analyses indicated that these patients had more hesitant responses for the related than for the unrelated condition. We propose that left middle temporal lesions affect the lexical activation component, making lexical selection more susceptible to errors.

AUTHORS

• Julia W.Y. Kam

• Anne-Kristin Solbakk

• Tor Endestad

• Torstein R. Meling

• Robert T. Knight

Date: 2018

DOI: 10.1016/j.neuroimage.2018.03.063

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Instantaneous voltage as an alternative to power- and phase-based interpretation of oscillatory brain activity

Abstract

For decades, oscillatory brain activity has been characterized primarily by measurements of power and phase. While many studies have linked those measurements to cortical excitability, their relationship to each other and to the physiological underpinnings of excitability is unclear. The recently proposed Function-through-Biased- Oscillations (FBO) hypothesis (Schalk, 2015) addressed these issues by suggesting that the voltage potential at the cortical surface directly reflects the excitability of cortical populations, that this voltage is rhythmically driven away from a low resting potential (associated with depolarized cortical populations) towards positivity (associated with hyperpolarized cortical populations). This view explains how oscillatory power and phase together influence the instantaneous voltage potential that directly regulates cortical excitability. This implies that the alternative measurement of instantaneous voltage of oscillatory activity should better predict cortical excitability compared to either of the more traditional measurements of power or phase. Using electrocorticographic (ECoG) data from 28 human subjects, the results of our study confirm this prediction: compared to oscillatory power and phase, the instantaneous voltage explained 20% and 31% more of the variance in broadband gamma, respectively, and power and phase together did not produce better predictions than the instantaneous voltage. These results synthesize the previously separate power- and phase-based interpretations and associate oscillatory activity directly with a physiological interpretation of cortical excitability. This alternative view has implications for the interpretation of studies of oscillatory activity and for current theories of cortical information transmission.

Authors

• Gerwin Schalk

• Joshua Marple

• Robert T. Knight

• William G. Coon

Date: 2017

DOI: 10.1016/j.neuroimage.2017.06.01

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Pre-stimulus thalamic theta power predicts human memory formation

ABSTRACT

Pre-stimulus theta (4–8 Hz) power in the hippocampus and neocortex predicts whether a memory for a subsequent event will be formed. Anatomical studies reveal thalamus-hippocampal connectivity, and lesion, neuroimaging, and electrophysiological studies show that memory processing involves the dorsomedial (DMTN) and anterior thalamic nuclei (ATN). The small size and deep location of these nuclei have limited real-time study of their activity, however, and it is unknown whether pre-stimulus theta power predictive of successful memory formation is also found in these subcortical structures. We recorded human electrophysiological data from the DMTN and ATN of 7 patients receiving deep brain stimulation for refractory epilepsy. We found that greater pre-stimulus theta power in the right DMTN was associated with successful memory encoding, predicting both behavioral outcome and post-stimulus correlates of successful memory formation. In particular, significant correlations were observed between right DMTN theta power and both frontal theta and right ATN gamma (32–50 Hz) phase alignment, and frontal-ATN theta-gamma cross-frequency coupling. We draw the following primary conclusions. Our results provide direct electrophysiological evidence in humans of a role for the DMTN as well as the ATN in memory formation. Furthermore, prediction of subsequent memory performance by pre-stimulus thalamic oscillations provides evidence that post-stimulus differences in thalamic activity that index successful and unsuccessful encoding reflect brain processes specifically underpinning memory formation. Finally, the findings broaden the understanding of brain states that facilitate memory encoding to include subcortical as well as cortical structures.

AUTHORS

• Catherine M. Sweeney-Reed

• Tino Zaehle

• Jürgen Voges

• Friedhelm Schmitt

• Lars Buentjen

• Klaus Kopitzki

• Alan Richardson-Klavehn

• Hermann Hinrichs

• Hans-Jochen Heinze

• Robert T. Knight

• Michael D. Rugg

Date: 2016

DOI: 10.1016/j.neuroimage.2016.05.042

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