Abstract:
Aging disrupts sleep. Moreover, these sleep impairments are exaggerated in Alzheimer’s disease, and are proposed to contribute to cognitive decline. Recent human studies have linked β-amyloid with non-rapid eye-movement (NREM) sleep disruption. However, the impact of tau pathology on human sleep oscillations and cognition remains uninvestigated. Here, we tested the hypothesis that tau burden within medial temporal lobe (MTL) impairs the coupled relationship between the two key NREM sleep oscillations—sleep spindles and slow waves, and their known support of hippocampal memory.
Authors:
Joseph R. Winer
Bryce A. Mander
Randolph F. Helfrich
Anne Maass
Theresa M. Harrison
Suzanne L. Baker
Robert T. Knight
William J. Jagust
Matthew P. Walker
Date: 2018
DOI: 10.1016/j.jalz.2018.06.2344