The Knight laboratory is a cognitive neuroscience research laboratory within the Helen Wills Neuroscience Institute and Department of Psychology at the University of California at Berkeley.

Neuropathology & Neuroscience

Agenesis of the corpus callosum in an infant

Agenesis of the corpus callosum in an adult

Chronic bilateral temporal damage from trauma. Note unilateral atrophy of the mammillary body due to loss of fornix input.

Chronic middle cerebral stroke

Posterior cerebral artery stroke

Chronic infarction. Entire distribution of the middle cerebral artery

Bacterial brain abcess in the depth of the frontal lobe

Neurocysticercosis cyst in the superior frontal gyrus. Note invaginated worm head in the cyst

Neurocysticercosis. Note multiple cysts

Knife-like atrophy of the frontal lobe in fronto-temporal dementia

Frontotemporal dementia: prominent lateral frontal atrophy

Frontotemporal dementia: prominent medial frontal atrophy

Glioblastoma in lateral frontal lobe

Thalamic glioblastoma

'Butterfly glioma' in the frontal lobe. Note tumor has spread through the corpus callosum

Multicystic glioblastoma centered in orbitofrontal cortex

Basal ganglia hemorrhage from hypertension

Pulvinar hemorrhage due to hypertension

Hemorrhagic stroke in the anterior cerebral artery involving medial prefrontal cortex

Hemorrhagic stroke in the middle cerebral artery involving middle and inferior frontal gyri

Hemorrhagic stroke posterior cerebral artery

Acute Wernicke-Korsakoff. Note petechial hemorrhages in the mammillary bodies and thalamus

Orbitofrontal meningioma

Medial frontal meningioma. Note extra-axial location

Massive orbitofrontal meningioma

Parasaggital meningioma

Orbitofrontal meningioma

Bilateral frontal leucotomy for treatment of psychiatric disorders. Note massive damage to white matter in frontal lobe

Focal cortical dysplasia in the lateral frontal lobe

Bullet track traversing bilateral frontal lobes

Huntington's Chorea

Chronic Herpes Simplex Encephalitis with Kluver-Bucy syndrome

Bullet through frontal lobe

Chronic bilateral temporal damage from trauma. Note unilateral atrophy of the mammillary body due to loss of fornix input

Temporal lobe contusions from traumatic brain injury

Massive frontal meningioma

Acute extensive hemorrhages in bilateral orbitofrontal cortex secondary to traumatic brain injury

Chronic extensive bilateral orbitofrontal damage to the orbitofrontal cortex from trauma. Note damage to both olfactory bulbs with resultant anosmia

Chronic unilateral orbitofrontal damage from trauma. Note damage to olfactory bulb on the side of tissue loss

Chronic orbitofrontal contusion

Szczepanski & Knight (2014). Neuron.